Mary-Louise Parker (born August 2, 1964) is an American actress. Some of her more famous roles were in Fried Green Tomatoes, Boys on the Side, Proof, The West Wing, Angels in America, for which she received a Golden Globe and an Emmy Award for Best Supporting Actress, and her current lead role on Showtime's television series Weeds portraying Nancy Botwin, for which she has received several nominations and the Golden Globe Award for Best Actress in 2006.
source : http://en.wikipedia.org/wiki/Mary-Louise_Parker